A Reliance Agreement, also referred to as an IRB Authorization Agreement, allows the IRB of one institution to rely on the IRB of another institution for review of human subjects research. The scope of the reliance agreement may be limited to a specific protocol or to any protocol agreed upon by both parties on a case-by-case basis. The following information is provided about requesting reliance on another institution for IRB review under an existing reliance agreement or requesting a new reliance agreement.
Brigham and Women’s Hospital (BWH), Faulkner Hospital, Massachusetts General Hospital (MGH), McLean Hospital (McLean) and North Shore Medical Center (NSMC) have all executed reliance agreements that allow them to rely on the Partners IRBs for review of human subjects research. The Partners IRBs are the IRBs registered to BWH, MGH and McLean. Newton-Wellesley Hospital and Spaulding Rehabilitation Hospital have executed reliance agreements with BWH and MGH so that they may rely on a single IRB for review of collaborative research with BWH and/or MGH.
BWH and MGH have executed a reliance agreement with Dana Farber Cancer Institute (DFCI) that allows BWH and MGH to rely on the DFCI IRB for review of certain oncology research.
Harvard Catalyst member institutions may request to rely on one another for IRB review of multi-site human subjects research. To submit a Harvard Catalyst Cede Review Request, use your eCommons login/password to login and complete the online Cede Review Form on the Catalyst website http://catalyst.harvard.edu/services/irbcede/. Note: You may request an eCommons login/password through the Catalyst website if you don’t have one.
BWH and MGH have executed reliance agreements with certain independent IRBs that allow BWH and MGH to rely on the independent IRB for review of industry-sponsored multi-site Phase III/IV clinical trials.